Aging is a phenomenon in which a cell's ability to divide and grow deteriorates as it gets older, and this causes degradation of the body and senile diseases. The inhibition and recovery of aging is an instinctive desire of humans; thus, it is a task and challenge of biologists to identify substances that control aging and analyze aging mechanisms.
DGIST's research team have been conducting research to reverse the aging process by shifting the existing academia's ‘irreversibility of aging' paradigm, which means aging cannot be reversed.
To reverse the aging process, the research team searched for factors that could control aging and tried to discover substances that could restore cell division capacity. As a result, it was confirmed that KU-60019, an inhibitor of ATM protein, which is a phosphorylation enzyme, recovers the functions of aging cells through activation of lysosomal functions and induction of cell proliferation.
The degradation of lysosomes, which are intracellular organelles responsible for autophagy and decomposition of biopolymers such as proteins and lipids in the cell, leads to cell senescence by accumulating biomolecules that must be removed in cells and causes instability of the metabolism such as removal of dysfunctional mitochondria that do not function.
The research team was the world's first to confirm that as cell aging progresses, the vacuolar ATPase (v-ATPase) protein involved in the lysosomal activity regulation is phosphorylated by the ATM protein, and the binding force between the units constituting the v-ATPase is weakened, so consequently, the function of lysosomes deteriorates.
In addition, the team has proven that the reversible recovery of aging is possible through its experiment that shows the regulation of ATM protein activation by KU-60019 substances induces the reduction of phosphorylation of v-ATPase, thereby inducing recovery of mitochondrial function and functional recovery of the lysosome and autophagy system as well as promoting wound healing in aging animal models.
DGIST Chair Professor Park SangChul said, “The significance and implication of this study is that it is possible to reverse the recovery of aging cells by inhibiting and restoring the degradation of lysosomal function. In the future, we will continue to conduct studies that extend the life expectancy of human beings by verifying and validating efficacy and safety through aging animal models.”
* Reversible aging: In a chemical reaction, when two substances are reacted at a specific concentration, pressure, temperature, etc., and a product is made, the reaction in which the first two substances are formed after reacting this product is called a reversible reaction. On the other hand, reactions that occur only in one direction are called irreversible reactions. Instead of seeing the aging of living organisms as they grow older as irreversible and inevitable, they see it as reversible and restorable; thus, the term ‘reversible aging' is used to denote such a reaction.
There is Already a Way Science Currently is Reversing Aging
Fortunately, science found a molecule that activates the regeneration of the telomeres, lengthening them, allowing our cells to duplicate over and over again, rebuilding our body anew, repairing damaged DNA, and reconstructing our organs to their original design.
Telomeres protect our DNA from fraying but when they become too short, the cells are no longer able to multiply. Telomeres are considered a biological clock; each time our cells divide, and the DNA replicates itself, the telomeres get shorter and shorter until the cells stop dividing and die, and ultimately the entire body is unable to regenerate itself and it dies too
In 1999, Elisabeth Blackburn was Laureate of the Nobel Prize for discovering the telomere activator enzyme named telomerase. Telomerase rebuilds the end of the telomeres to their original length after each cell division, halting the biological death-clock. But telomerase is generated less and less in the cells, as years go by, and that’s where Epitalon comes in.
Epithalamin (Epitalon or epithalon) was found in extracts from a region of the brain called the epithalamus. This region contains the pineal gland, or “third eye” and “Gods Antennae”, which controls wake/sleep cycles and is the body’s source of melatonin and telomerase. Epitalon was shown to stimulate evening melatonin production and normalize circadian rhythms of cortisol through the day and night.
Prof. Vladimir Khavinson discovered Epithalamin (and synthesized its equivalent, Epitalon) over 30 years ago, while working for the Soviet military, and has been studying it ever since. There are over a 100 published studies, on PubMed alone, showing the beneficial effects of Epitalon and epithalamin. These studies have proven that the length of telomeres increases after taking this peptide, orally, and the humans taking it live longer than those who don’t.
Epitalon is an amazing anti-aging peptide that works on all levels of cellular health, Pineal Gland rejuvenation, and DNA repair. The following benefits are noted.
- Activating telomerase.
- Elongating telomeres.
- Promoting cellular survival and resistance to stress and oxidative changes.
- Balancing endocrine secretions, rejuvenating Pineal Gland function and increasing melatonin release.
- Specifically attenuating excess cortisol secretions from the higher level.
- Can increase antioxidant enzymes.
- Increase brain health, stave brain cell aging/remodeling.
- Restore quality of life and extend the lifespan by all above mechanisms.
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