As we age, melatonin content in our blood decreases considerably. This hormone plays a key role in our bio-rhythm control and effects the endocrine, nervous and immune systems. In fact, reduced melatonin production leads to age-related neurodegenerative changes and certain diseases.

Melatonin's importance is clear, however, supplementing melatonin, in some cases, can provoke considerable side-effects, such as neoplastic growth. Finding a suitable way to safely increase melatonin levels is an important endeavor, indeed!

Vladimir Khavinson
Vladimir Khavinson


Epithalamin is a complex of peptides found in the pineal gland that helps in the production/release of melatonin, naturally. Epitalon is a tetrapeptide, synthetic version of epithalamin.

In a research study, led by Vladimmir Khavinson, they monitored the effects of Epitalon on 2 groups of female monkeys (6 young and 6 older). The results were quite impressive!

Effect Epitalon on Melatonin Levels
Effect of Epitalon on Melatonin Levels

Melatonin content in the aging group of monkeys (before Epitalon) was shown to be half the levels in the younger group, from the start. But once Epitalon was introduced to the older group, their melatonin levels increased more than 3 times, compared to the older control group!

Interestingly, in the younger group, no significant increase of melatonin was observed, at all. Essentially, their body ‘knew' it didn't need anymore.


What was also shown is Cortisol levels reached a normalizing effect in the aging monkeys with Epitalon.

Cortisol normally increases in the morning and decreases in the evening, resulting in a normal circadian rhythm, leading to a proper sleep pattern. In the aging monkeys control group (no epitalon) morning levels of cortisol were significantly less than normal, and their evening levels actually increased, which is dramatically higher than normal!

The aging monkeys, receiving epitalon, had nearly normal levels of cortisol, in the morning and the evening.

Effect of Epitalon on Cortisol Levels

Normalized production of melatonin and cortisol is essential to the body, since it is the circadian rhythms of these hormones that determine the daily rhythmic activity of various organs, and above all, of the nervous, endocrine, cardiovascular and immune systems.

These results point to the use of Epitalon in the correction of age-related hormonal imbalance, and functional normalization of the vitally important organs and systems.

Experimental and clinical studies of Epitalon showed the following pharmaclogical properties of  Epitalon:

* Telomerase activation (consequently, elongation of Telomeres) * regulates neuroendocrinous system * increases the hypothalamic sensitivity to the endogenous hormonal effects * decrease or suppression of proliferative changes in vaginal epithelium and endometrium in anovulatory phase * normalization of gonadotropic hormones levels (FSG, LG, prolactin) * positive influence on peripheral haemodynamics: improvement of blood rheology, decrease of intravessel thrombogenesis * regulation of the levels of reactants in the acute inflammation phase (c3-component of the complement, pre-albumin, C-reactive protein, alpha-orosomucoids * normalization of T-cell immunity * normalization of aqua-electrolyte balance indices * normalization of uric acid levels * normalization of Cholesterol * rejuvenation / strengthening of the immune system * inhibition of spontaneous and induced carcinogenesis (tumor prevention)

Where can one find Epitalon?

Epitalon has been studied for decades, with no negative side-effects shown. But, until recently, one couldn't obtain it. But that isn't the case anymore. But the sources are limited. We recommend ordering from OceansLab.



Korkushko OV, Lapin BA, Goncharova ND, Khavinson VK, Shatilo VB, Vengerin AA, et al. Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys & elderly people. Adv Gerontol. 2007;20(1):74-85.

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