Does Exercise Really Increase Longevity and Telomere Health?

From boosting happiness to providing an energy boost, the benefits of exercise are well documented. Now there’s another reason to hit the gym.

Scientists in Germany gathered several groups of men and women to look at their cells’ life spans. Some of them were young and sedentary, others middle-aged and sedentary. Two other groups were, to put it mildly, active. The first of these consisted of professional runners in their 20s, most of them on the national track-and-field team, training about 45 miles per week. The last were serious, middle-aged longtime runners, with an average age of 51 and a typical training regimen of 50 miles per week, putting those young 45-mile-per-week sluggards to shame.

From the first, the scientists noted one aspect of their older runners. It ‘‘was striking,’’ recalls Dr. Christian Werner, an internal-medicine resident at Saarland University Clinic in Homburg, ‘‘to see in our study that many of the middle-aged athletes looked much younger than sedentary control subjects of the same age.’’

telomeres_tnEven more striking was what was going on beneath those deceptively youthful surfaces. When the scientists examined white blood cells from each of their subjects, they found that the cells in both the active and slothful young adults had similar-size telomeres. Telomeres are tiny caps on the end of DNA strands — the discovery of their function won several scientists the 2009 Nobel Prize in medicine. When cells divide and replicate these long strands of DNA, the telomere cap is snipped, a process that is believed to protect the rest of the DNA but leaves an increasingly abbreviated telomere. Eventually, if a cell’s telomeres become too short, the cell ‘‘either dies or enters a kind of suspended state,’’ says Stephen Roth, an associate professor of kinesiology at the University of Maryland who is studying exercise and telomeres. Most researchers now accept telomere length as a reliable marker of cell age. In general, the shorter the telomere, the functionally older and more tired the cell.

It’s not surprising, then, that the young subjects’ telomeres were about the same length, whether they ran exhaustively or sat around all day. None of them had been on earth long enough for multiple cell divisions to have snipped away at their telomeres. The young never appreciate robust telomere length until they’ve lost it.

blog_telomere_tnWhen the researchers measured telomeres in the middle-aged subjects, however, the situation was quite different. The sedentary older subjects had telomeres that were on average 40 percent shorter than in the sedentary young subjects, suggesting that the older subjects’ cells were, like them, aging. The runners, on the other hand, had remarkably youthful telomeres, a bit shorter than those in the young runners, but only by about 10 percent. In general, telomere loss was reduced by approximately 75 percent in the aging runners. Or, to put it more succinctly, exercise, Dr. Werner says, ‘‘at the molecular level has an anti-aging effect.’’

There are plenty of reasons to exercise — in this column, I’ve pointed out more than a few — but the effect that regular activity may have on cellular aging could turn out to be the most profound. ‘‘It’s pretty exciting stuff,’’ says Thomas LaRocca, a Ph.D. candidate in the department of integrative physiology at the University of Colorado in Boulder, who has just completed a new study echoing Werner’s findings. In Mr. LaRocca’s work, people were tested both for their V02max — or maximum aerobic capacity, a widely accepted measure of physical fitness — and their white blood cells’ telomere length. In subjects 55 to 72, a higher V02max correlated closely with longer telomeres. The fitter a person was in middle age or onward, the younger their cells.

Epitalon and Telomerase

Gene expression is different in young, middle-aged, and old individuals. The body times the life cycle using gene expression. In childhood, genes dictate the body to grow, in the middle age they maintain the body strong and healthy, and in the old age they dictate the body to stop releasing vital hormones, thus slowing down life processes and destroying the body.

Telomerase (a.k.a. telomere terminal transferase) is the enzyme capable to elongating telomeres in human bodies while protecting the DNA from the damage caused by aging. When cells multiply, they are set a predefined number of cycles they can perform the divisions due to the permanent curtailment of telomeres. In Mr. Khavinson’s studies, Epitalon treated cells made a total of forty-four passages (ten extra divisions compared to normal cells). Thus, the studies support the evidence that Epitalon prolongues the life of cells due to overcoming of the Heyflick division limit.

Imagine the boost one can have with Exercise and the addition Epitalon! With Epitalon, one can begin to apply these findings immediately, because it's available now through OceansLab.



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