Shorter telomeres have previously been linked to increased risk of death from heart disease. Now, change in telomere length over time has also been found to be important.
Research by scientists, at UC San Francisco and the Veterans Affairs Medical Center in San Francisco, found that heart disease patients whose telomeres shrank over time had a worse short-term prognosis than those whose telomeres stayed stable. Furthermore, those whose average telomere length grew over the course of the study had a higher chance of survival.
Telomere length has emerged as a leading biomarker of aging and predicts early onset of cardiovascular disease. In older people with stable heart disease, longevity can vary widely, but a number of studies have suggested that telomere length appears to be a good predictor of a patient’s likely health span — their number of healthy years of life remaining.
However, previous studies evaluating telomere length in white blood cells called leukocytes as a predictor of mortality have produced inconsistent findings, only sometimes predicting mortality.
RATE OF TELOMERE CHANGE
The new study was directed by Mary Whooley, MD, professor of medicine and epidemiology biostatistics at UCSF. Researchers investigated whether the rate of telomere change, rather than absolute telomere length, might be a better predictor of health span in heart disease patients.
The team tracked health outcomes over nine years for 608 men and women with stable cardiovascular disease who were enrolled in the UCSF-led Heart and Soul Study. The researchers measured patients’ leukocyte telomere length at the start of the study and again five years later, and then examined whether the difference between these measurements predicted which patients were most likely to die over the next four years.
Overall, one-quarter of patients had died by the end of the study, but only 12 percent of patients whose telomeres had lengthened during the five-year observation period were among this group.
In contrast, 39 percent of patients whose telomeres had shrunk in the five-year observation period died within the next four years. Of those whose telomere length had remained stable, 22 percent had died by the end of the study.
PROTECTIVE TELOMERE LENGTHENING
The researchers found that these three groups were similar in traditional cardiovascular risk factors such as blood pressure, BMI, and cholesterol levels. However, those whose telomeres shortened over the course of the study also showed higher abdominal fat, worse kidney function, and lower overall fitness.
Controlling for these and other factors, the researchers found that those whose telomeres shortened over five years were 32 percent more likely to die during the next four years than those whose telomeres stayed the same, and those who experienced telomere lengthening were 56 percent less likely to die.
“This study goes beyond telomere length as a single measure and shows that the rate of change may also be an important predictive factor,” Whooley said. “It also shows, rather surprisingly, that a substantial number of people had telomere lengthening, and that this appeared to be protective.”
An earlier UCSF study found that greater exposure to stressful events predicts telomere shortening over one year, but that participants who maintained a healthy lifestyle — including sufficient sleep, a healthy diet, and regular exercise — did not show the shortening.
“While we have observed in several studies that average telomere length can get longer over the period of a year or two, we think the more common process is that a healthy lifestyle protects telomeres and leads to less shortening, more stability, and thus better telomere maintenance over the years,” said study co-author Elissa Epel, PhD, a professor of psychiatry and director of the Aging, Metabolism, and Emotions Lab at UCSF.
How to Protect and Restore Your Telomeres
Co-author Elizabeth Blackburn, PhD, a professor emeritus at UCSF and 2009 recipient of the Nobel Prize in Physiology or Medicine for her co-discovery of the telomerase enzyme, added:
“Telomere lengthening appears to happen in people and may be a meaningful phenomenon. Fortunately, there are multiple ways to protect telomere length throughout the lifespan.”
Among the research-vetted ways to protect telomeres, the authors cite avoiding smoking, getting at least 150 minutes of moderate exercise or 75 minutes of vigorous exercise per week, and maintaining a healthy, low-fat diet.
Another, proven way of increasing one’s telomere length and health is the tetrapeptide – Epitalon. Well researched and documented, Epitalon stimulates the pineal gland to produce telomerase – the body’s way of protecting and increasing telomere length. Epitalon has also been shown to balance the body’s melatonin and cortisol levels, resulting in a productive sleep-cycle.
If that wasn’t enough, Epitalon also helps with the normalization of T-cell immunity, Hormonal balance, the normalization of Cholesterol, rejuvenation/strengthening of the Immune System, inhibition of spontaneous and induced carcinogenesis (Tumor Prevention).
The exciting discoveries of Epitalon and health are continuing to show it’s ability to help our fight against disease and to live Longer, Healthier lives.
You don’t have to wait to discover how Epitalon could be helping you, and those you love. This is something you can do for yourself, Today!
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journals.plos.org – Sarah E. Goglin et al.
– Biological stability evaluation of the a2B1 receptor imaging agents: diamsar and DOTA conjugated DGEA peptide.
Huang CW, Li Z, Cai H, Shahinian T, Conti PS. Bioconjug Chem. 2011 Feb 16;22(2):256-63. doi: 10.1021/bc100388g. Epub 2011 Jan 18.
– [The use of peptide bioregulators for cancer prevention: results of 35 years of research experience and perspectives].
Anisimov VN, Khavinson VKh. Vopr Onkol. 2009;55(3):291-304. Review. Russian. No abstract available.
– Geroprotective effect of ala-glu-asp-gly peptide in male rats exposed to different illumination regimens.
Vinogradova IA, Bukalev AV, Zabezhinski MA, Semenchenko AV, Khavinson VKh, Anisimov VN. Bull Exp Biol Med. 2008 Apr;145(4):472-7.
– Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes.
Vinogradova IA, Bukalev AV, Zabezhinski MA, Semenchenko AV, Khavinson VKh, Anisimov VN. Bull Exp Biol Med. 2007 Dec;144(6):825-30.
– [The effect of heavy metal ions and peptide bioregulators on the expression of chromosome fragile sites in the individuals of different age groups and breast cancer patients].
Dzhokhadze TA, Ganozishvili MN, Lezhava TA. Georgian Med News. 2008 Sep;(162):11-4. Russian.
– Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice.
Kossoy G, Anisimov VN, Ben-Hur H, Kossoy N, Zusman I. In Vivo. 2006 Mar-Apr;20(2):253-7.
PMID: 16634527 – Free Article
– [Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)].
Anisimov VN, Popovich IG, Zabezhinskii MA, Rozenfel’d SV, Khavinson VKh, Semenchenko AV, Iashin AI. Vopr Onkol. 2005;51(1):93-8. Russian.
– [The influence of substances revealing geroprotective of spontaneous carcinogenesis in mice].
Popovich IG. Adv Gerontol. 2004;14:105-13. Review. Russian.